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Table 3 Follow-up cost and frequency

From: The cost-effectiveness analysis of newborn screening for inherited metabolic disorders in China using tandem mass spectrometry: a real-world evidence

Item

Unit price

Whether to carry out this test (1 is yes, and 0 is no)

MMA

PA

IVA

BKD

MCCD

HMG

HCS

Ga-I

PCD

SCADD

SCHADD

MCADD

Frequency (Times)

             

MS/MS

250

1

1

1

1

1

1

1

1

1

1

1

1

Blood gas

117

1

1

1

1

1

1

1

1

1

0

1

1

Blood ammonia

40

1

1

1

1

1

1

0

1

1

0

1

1

Blood homocysteine

120

1

1

0

0

0

0

0

0

0

0

0

0

liver function

190

1

1

0

1

1

1

0

1

1

0

1

1

Phenylalanine

18

0

0

0

0

0

0

0

0

0

0

0

0

Alpha fetoprotein

32

0

0

0

0

0

0

0

0

0

0

0

0

Urine gas chromatography

258

1

1

1

1

1

1

1

1

1

1

1

1

Routine blood test

20

1

1

0

1

0

0

1

1

0

0

0

0

Blood biochemistry

181

1

1

1

1

1

1

0

1

1

0

1

1

Trace element

39

0

0

1

0

0

0

0

0

0

0

0

0

Echocardiography

225

0

0

0

0

0

0

0

0

1

0

0

0

Electrocardiogram

20

0

0

0

0

0

0

0

0

1

0

0

0

Magnetic resonance

620

1

1

1

0

0

1

0

1

0

0

0

0

Electroencephalogram

45

1

1

0

0

0

0

0

0

0

0

1

0

Urinalysis

10

0

0

0

1

0

1

1

1

0

0

0

0

Myocardial zymogram

210

0

0

0

0

0

0

0

0

0

0

0

0

Blood fat

45

0

0

0

0

0

0

0

0

0

0

0

0

Annual cost of early diagnosis (CNY): 1 to 5 years old

N/A

7,364

1,841

1,505

1,066

1,036

1,666

655

1,686

1,281

508

1,081

1,036

Annual cost of early diagnosis (CNY): After 5 years old

N/A

1,841

1,841

1,505

1,066

1,036

1,666

655

1,686

1,281

508

1,081

1,036

Annual cost of late diagnosis (CNY): 1 to 5 years old

N/A

11,046

11,046

9,030

6,396

6,216

9,996

3,930

10,116

7,686

3,048

6,486

6,216

Annual cost of late diagnosis (CNY): After 5 years old

N/A

5523

5523

4515

3198

3108

4998

1965

5058

3843

1524

3243

3108

Item

Unit price

 

Whether to carry out this test (1 is yes, and 0 is no)

VLCADD

LCHAD

GaII

NICCD

CIT-I

OTC

CPS1

ARG

MET

MSUD

TYR

PKU

Frequency (Times)

             

MS/MS

250

1

1

1

1

1

1

1

1

1

1

1

1

Blood gas

117

1

1

1

0

0

1

1

1

0

1

0

0

Blood ammonia

40

1

1

0

1

1

1

1

1

0

1

0

0

Blood homocysteine

120

0

0

0

0

0

0

0

0

1

0

0

0

liver function

190

1

1

1

1

1

1

1

1

1

0

1

0

Phenylalanine

18

0

0

0

0

0

0

0

0

0

0

0

1

Alpha fetoprotein

32

0

0

0

1

0

0

0

0

0

0

1

0

Urine gas chromatography

258

1

1

1

1

1

1

1

1

0

1

1

1

Routine blood test

20

0

0

0

0

0

0

0

0

0

0

1

0

Blood biochemistry

181

1

1

1

1

0

0

0

0

0

1

1

0

Trace element

39

0

0

0

0

0

0

0

0

0

0

0

0

Echocardiography

225

0

0

0

0

0

0

0

0

0

0

0

0

Electrocardiogram

20

0

0

0

0

0

0

0

0

0

0

0

0

Magnetic resonance

620

0

0

1

0

0

0

0

1

1

1

1

0

Electroencephalogram

45

0

0

0

0

0

0

0

0

0

0

0

0

Urinalysis

10

1

1

0

0

0

0

0

0

0

1

1

0

Myocardial zymogram

210

0

0

1

0

0

0

0

0

0

0

0

0

Blood fat

45

0

0

0

1

0

0

0

0

0

0

0

0

Annual cost of early diagnosis (CNY): 1 to 5 years old

N/A

4,184

4,144

4,184

7,304

3,984

2,952

3,420

3,420

5,900

4,720

5,904

2,104

Annual cost of early diagnosis (CNY): After 5 years old

N/A

1,046

1,036

1,046

1,826

996

738

855

855

1,475

1,180

1,476

526

Annual cost of late diagnosis (CNY): 1 to 5 years old

N/A

6,276

6,276

10,956

5,976

4,428

5,130

5,130

8,850

7,080

8,856

9,366

3,156

Annual cost of late diagnosis (CNY): After 5 years old

N/A

3138

3138

5478

2988

2214

2565

2565

4425

3540

4428

4683

1578