Table 1 Burkitt’s Lymphoma Treatment protocol in Ghana
Tumor stage | Course of treatment |
|---|---|
Stages I, II & III | A pre-phase dose of IV cyclophosphamide 1400 mg/m2 with IT methotrexate, followed by a combination chemotherapy consisting of 6 cycles (cyclophosphamide, vincristine and doxorubicin alternating with cyclophosphamide, vincristine and cytarabine every 2 weeks) with IT methotrexate given during the first 3 courses |
Stage IV | For bone marrow involvement a modified version of a mature B-cell protocol for high income countries without rituximab is used, and inclusive of four cycles of maintenance therapy, following reduction, induction and consolidation phases of therapy. For CNS disease, additional intrathecal therapy is included until cerebrospinal fluid (CSF) cytology is negative |