Table 1 Key model parameters

• Patient characteristics [14, 20, 21]

 Age (y), mean (SD)

60 (13.4)

Normal

 Body weight (kg), mean (SD)

77 (3.8)

Normal

 Starting HAQ score, mean (SD)

1.65 (0.168)

Normal

 Disease duration, mean (SD)

6.1 (0.8)

Normal

 Sex: female, %

80

Normal

• HAQ score change by ACR response levels (6 months), mean (SD) [14, 20]

 Non-responder

−0.11 (0.056)

Normal

 < ACR20

−0.44 (0.056)

Normal

 ACR20-50

−0.76 (0.092)

Normal

 ACR > 70

−1.07 (0.179)

Normal

 Palliative care

0.03 (0.005)

Normal

• Hospital days per year by HAQ score, mean [14]

 0.0–0.5

0.26

-

 0.6–1.0

0.13

-

 1.1–1.5

0.51

-

 1.6–2.0

0.72

-

 2.1–2.5

1.86

-

 2.6–3.1

4.16

-

• Probability of Nonresponse [1, 22]

 ADA

0.5

Beta

 ETC

0.29

Beta

 RTX

0.49

Beta

 TCZ

0.34

Beta

• Proportion of lack of efficacy [23,24,25]

 ADA

15%

-

 ETC

30%

-

 RTX

40%

-

 TCZ

18%

-

• Other inputs

 Cost discount rate

5.8%

-

 Utility discount rate

5.8%

-