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Table 2 QALYs gained, intervention and treatment costs by intervention

From: Cost-utility analysis of prenatal diagnosis of congenital cardiac diseases using deep learning

 

Null

US

POX

US

Deep

Deep

 

Routine (a)

Routine & POX

Learning-US

Learning-US & POX

Costs (million nis)

 Intervention Cost

55.7

80.7

59.0

83.8

103.3

106.3

 Treatment Cost

461.3

423.2

461.8

423.4

402.9

403.0

 Total Costs

517.0

503.9

520.8

507.2

506.2

509.3

 Net Costs cf: null

 

− 13.1

3.8

− 9.8

− 11.8

− 7.7

QALY losses

 Mothers: Abortions

431.9

458.2

431.9

458.2

845.3

845.3

 Mothers: Miscarriages

4088

4076

4088

4076

4069

4069

 Mothers: Stillbirths

411

410.9

411.3

410.9

410.7

410.7

 Mothers: Neonatal Mortality

91

47

43

27

22

19

 Parents: due to Childs CHD

50

47

50

47

44

44

 Patient: CHD lifetime

21,573

19,748

21,549

19,738

18,165

18,164

TOTAL QALY loss

26,646

24,787

26,573

24,756

23,556

23,552

 QALYs gained cf null

 

1858

73

1889

 3089

3093

Average Cost-

 Effectiveness Ratio (b)

 

dom

50,882

dom

dom

dom

 (USD per QALY gained)

      
  1. (a) based on retrospective “routine reports”
  2.  (b) dom: denotes intervention dominates the null by providing more QALYS at no additional cost
  3. Screening costs: US ($124.42), DL ($144.82)
  4. DL Sensitivity (95%), Specificity (96%)