Table 4 Methodological analysis of included papers

Analysis

Cost Utility

11

(79)

257

(73)

268

(74)

Cost Effectiveness

3

(21)

88

(25)

91

(25)

Not Reported

0

(0)

4

(1)

4

(1)

Cost Minimization

0

(0)

1

(0)

1

(0)

Model

No Model Used

3

(21)

125

(36)

128

(35)

 Trial Based Economic Evaluations

2

(14)

115

(32)

117

(32)

Markov Model

7

(50)

100

(29)

107

(29)

Decision Tree

0

(0)

94

(27)

94

(26)

Microsimulation

3

(21)

19

(5)

22

(6)

Undetermined Model Used

1

(8)

12

(3)

13

(4)

Perspective

Payer

7

(50)

201

(57)

208

(57)

Societal

5

(36)

75

(21)

80

(22)

Institutional

0

(0)

18

(5)

18

(5)

Not Reported

2

(14)

56

(16)

58

(16)

Time horizon

Limited

10

(71)

194

(55)

204

(56)

 Mean Time Horizon (Months)

80

398

400

Lifelong

3

(21)

65

(19)

68

(19)

Not Reported

1

(8)

91

(26)

92

(25)

Sensitivity analyses

Probabilistic/Bootstrap

9

(64)

257

(73)

266

(73)

Deterministic

12

(86)

294

(84)

306

(84)

Value of Information Analyses

3

(21)

2

(0)

5

(1)

Source cost data

Hospital Database

1

(8)

72

(21)

73

(20)

Literature

5

(36)

101

(29)

106

(29)

Public Database

6

(42)

89

(25)

95

(26)

Clinical Research

2

(14)

79

(23)

81

(22)

Microcosting

0

(0)

3

(1)

3

(1)

Not Reported

0

(0)

6

(2)

6

(2)

Source effectiveness data

Literature

10

(71)

189

(54)

199

(55)

Clinical Research

3

(21)

120

(35)

123

(34)

Hospital Database

0

(0)

21

(6)

21

(6)

Clinical Database

1

(8)

19

(5)

20

(5)

Not Reported

0

(0)

1

(0)

1

(0)

Publication characteristics

CHEERS Declared by Authors

3

(21)

80

(23)

83

(23)

HEOR Journal

4

(29)

38

(11)

42

(12)

Clinical Journal

8

(57)

295

(84)

303

(83)

Other Journal

2

(14)

17

(5)

19

(5)