Fig. 5

Cost-effectiveness acceptability curves for two treatment strategies based on the uncertainty in cost and quality-adjusted life year (QALY) on January 1 of 2019, 2024, 2029 and 2034. Strategy 1 consists of five available non-steroidal anti-inflammatory drugs (NSAIDs) and Strategy 2 consists of the same available NSAIDs as in Strategy 1 and two tumour necrosis factor-α antagonists (anti-TNF agents). The four curves were obtained from simulations with four different time spans of decision, 5, 10, 15 and 20 years