Fig. 1

Markov model state transition diagram. Within each state a patient can experience any one of the following events: (1) no exacerbation (NoEx), (2) non-severe exacerbation (Ex), (3) severe exacerbation (SevEx)
Markov model state transition diagram. Within each state a patient can experience any one of the following events: (1) no exacerbation (NoEx), (2) non-severe exacerbation (Ex), (3) severe exacerbation (SevEx)